Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
marRTranscriptional regulator; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)    
Predicted Functional Partners:
AKL36137.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.938
marA_4
Transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.923
soxR
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.630
tolC
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.619
gcvA_3
Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family.
   
  
 0.562
marC_3
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.524
slyA
Transcriptional regulator SlyA; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family.
  
   
 0.509
nfsA
NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the flavin oxidoreductase frp family.
  
  
 0.508
rfaD
ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
      
 0.501
emrB
Multidrug resistance protein B; Multidrug MFS transporte; with EmrA is involved in resistance to hydrophobic antibiotics such as nalidixic acid; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the major facilitator superfamily.
 
  
 0.500
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
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