Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pspEThiosulfate:cyanide sulfurtransferase; Rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; Derived by automated computational analysis using gene prediction method: Protein Homology. (104 aa)    
Predicted Functional Partners:
pspD
Phage-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.804
pspB
Phage shock protein; DNA-binding transcriptional regulator; acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.766
pspC
Transcriptional regulator; With PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.733
pspA
Phage shock protein; Involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.691
AKL38889.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.607
grxC
Glutaredoxin; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
  
  
 0.576
smpA
Membrane biogenesis protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
   
    0.570
AKL36703.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.543
glpE
Thiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
  
  
 0.508
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
   0.497
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
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