Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lpoBPenicillin-binding protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (211 aa)    
Predicted Functional Partners:
AKL36923.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.979
thiK
Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate.
 
  
 0.959
AKL36924.1
Purine nucleoside phosphoramidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.891
mrcB
Bifunctional glycosyl transferase/transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
  
 
 
 0.870
ftsN
Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
  
   
 0.834
AKL36775.1
Transcriptional regulator; Osmotically-inducible lipoprotein E; activator of ntr-like gene protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.775
ycfR_2-2
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.772
nagZ
Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
  
    0.771
yhcN
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.769
ydgH
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.768
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
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