Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pflAPyruvate formate lyase-activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)    
Predicted Functional Partners:
pflB
Pyruvate formate-lyase; Formate acetyltransferase; catalyzes the formation of formate and acetyl-CoA from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.964
pflD
Formate acetyltransferase; Involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.867
AKL37303.1
Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.859
cutC-2
Formate acetyltransferase; Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde. Belongs to the glycyl radical enzyme (GRE) family. CutC subfamily.
 
  
 0.822
grcA
Autonomous glycyl radical cofactor GrcA; Acts as a radical domain for damaged PFL and possibly other radical proteins.
  
   
 0.782
AKL35823.1
Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
 
  
 0.680
nasB
Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.662
pflA_3
Ribonucleoside-triphosphate reductase; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
 
   
 0.566
nifJ
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.563
AKL37227.1
Formate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.527
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
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