Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKL37253.1Confers macrolide resistance via active drug efflux; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (371 aa)    
Predicted Functional Partners:
macB_1
Macrolide transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.991
lolD-2
Macrolide transporter; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
 
 
 0.932
AKL34766.1
Macrolide transporter; With MacA is involved in the export of macrolide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
 
 
 0.931
tolC
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.925
bepC
Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.662
AKL38863.1
Heavy metal RND transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.656
AKL33770.1
Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.618
AKL35545.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
  0.618
acrB_1
Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.614
AKL36512.1
Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.614
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
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