Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
leuO-2Transcriptional regulator; Activator for leuABCD operon; member of LysR family of transcriptional activators; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (316 aa)    
Predicted Functional Partners:
chbR
Transcriptional regulator; Represses the celABCDF-ydjC operon involved in carbon uptake; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.610
AKL35291.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.533
yjjQ
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.502
AKL34228.1
Porin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.453
bcsE
Required for cellulose biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.449
AKL38296.1
XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.432
osmB
Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.422
AKL33932.1
Cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.415
sbmC
DNA gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
  
     0.415
AKL37371.1
acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.406
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
Server load: low (22%) [HD]