AKU15604.1 protein (Luteipulveratus mongoliensis)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

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[Homology]

Score

AKU15604.1

GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)

Predicted Functional Partners:

AKU16316.1

0.573

AKU19272.1

0.532

AKU17363.1

0.511

AKU15825.1

0.483

AKU14690.1

0.454

AKU15603.1

0.442

Your Current Organism:

Luteipulveratus mongoliensis

NCBI taxonomy Id: 571913
Other names: Dermacoccaceae bacterium MN07-A0370, L. mongoliensis, Luteipulveratus mongoliensis Ara et al. 2010, NBRC 105296, VTCC D9-09, strain MN07-A0370

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKU14690.1	AKU15604.1	VV02_00400	VV02_06615	Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.454
AKU14690.1	AKU16316.1	VV02_00400	VV02_11340	Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.419
AKU15603.1	AKU15604.1	VV02_06610	VV02_06615	Neutral/alkaline nonlysosomal ceramidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.442
AKU15604.1	AKU14690.1	VV02_06615	VV02_00400	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.454
AKU15604.1	AKU15603.1	VV02_06615	VV02_06610	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Neutral/alkaline nonlysosomal ceramidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.442
AKU15604.1	AKU15825.1	VV02_06615	VV02_08095	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.483
AKU15604.1	AKU16316.1	VV02_06615	VV02_11340	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.573
AKU15604.1	AKU17363.1	VV02_06615	VV02_18410	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.511
AKU15604.1	AKU19272.1	VV02_06615	VV02_24280	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Penicillin acylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.532
AKU15825.1	AKU15604.1	VV02_08095	VV02_06615	Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.483
AKU16316.1	AKU14690.1	VV02_11340	VV02_00400	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.419
AKU16316.1	AKU15604.1	VV02_11340	VV02_06615	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.573
AKU16316.1	AKU17363.1	VV02_11340	VV02_18410	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.490
AKU17363.1	AKU15604.1	VV02_18410	VV02_06615	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.511
AKU17363.1	AKU16316.1	VV02_18410	VV02_11340	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.490
AKU19272.1	AKU15604.1	VV02_24280	VV02_06615	Penicillin acylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GDSL family lipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.532

Network Stats

number of nodes:

7

number of edges:

8

average node degree:

2.29

avg. local clustering coefficient:

0.829

expected number of edges:

6

PPI enrichment p-value:

0.293

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032446

Protein modification by small protein conjugation

9 of 195

1.86

4.35

8.06e-13

GO:0016567

Protein ubiquitination

8 of 176

1.85

4.05

1.13e-11

GO:0019941

Modification-dependent protein catabolic process

9 of 249

1.75

3.85

2.88e-12

GO:0006511

Ubiquitin-dependent protein catabolic process

8 of 241

1.71

3.42

9.55e-11

GO:0036211

Protein modification process

11 of 932

1.26

2.08

7.05e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

4 of 31

2.3

2.63

8.04e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031461

cullin-RING ubiquitin ligase complex

5 of 54

2.16

3.29

1.56e-07

GO:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.28

1.11e-06

GO:0019005

SCF ubiquitin ligase complex

3 of 22

2.33

2.11

9.49e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2915

Protein neddylation, and SCF ubiquitin ligase complex

8 of 24

2.72

8.54

1.14e-17

CL:2914

cullin-RING ubiquitin ligase complex, and COP9 signalosome

9 of 42

2.52

8.51

1.16e-18

CL:2918

Protein neddylation, and SCF ubiquitin ligase complex

7 of 19

2.76

7.62

1.53e-15

CL:2920

Mixed, incl. Nuclear SCF ubiquitin ligase complex, and Cullin

4 of 10

2.79

3.99

3.72e-08

CL:2923

Nuclear SCF ubiquitin ligase complex, and SKP1 component, POZ domain

2 of 5

2.79

1.41

0.0027

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

8 of 131

1.98

4.85

3.81e-13

map04111

Cell cycle - yeast

5 of 156

1.7

2.29

2.34e-06

map04141

Protein processing in endoplasmic reticulum

5 of 221

1.55

1.92

8.49e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

6 of 148

1.8

2.77

2.04e-07

MAP-983169

Class I MHC mediated antigen processing & presentation

6 of 217

1.63

2.3

9.54e-07

MAP-1280218

Adaptive Immune System

6 of 301

1.49

1.91

4.32e-06

MAP-9020702

Interleukin-1 signaling

2 of 14

2.35

1.12

0.0086

MAP-446652

Interleukin-1 family signaling

2 of 14

2.35

1.12

0.0086

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031461

cullin-RING ubiquitin ligase complex

6 of 65

2.16

4.06

1.88e-09

GOCC:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.31

9.96e-07

GOCC:0017117

Single-stranded DNA-dependent ATP-dependent DNA helicase complex

3 of 3

3.19

3.31

9.96e-07

GOCC:0043291

RAVE complex

3 of 5

2.97

3.14

1.86e-06

GOCC:0019005

SCF ubiquitin ligase complex

3 of 37

2.1

1.86

0.00022

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045093

Cullin

3 of 4

3.07

2.57

2.20e-05

IPR001373

Cullin, N-terminal

3 of 5

2.97

2.56

2.20e-05

IPR016159

Cullin repeat-like-containing domain superfamily

3 of 6

2.89

2.55

2.20e-05

IPR019559

Cullin protein, neddylation domain

2 of 3

3.02

1.4

0.0030

IPR036317

Cullin homology domain superfamily

2 of 4

2.89

1.35

0.0036

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 3

3.02

1.6

0.0013

SM00182

Cullin

2 of 3

3.02

1.6

0.0013

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