node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEA69844.1 | fhs | SAMN05421743_10760 | SAMN05421743_106178 | Ribose 5-phosphate isomerase B. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.678 |
SEA69844.1 | folD | SAMN05421743_10760 | SAMN05421743_11855 | Ribose 5-phosphate isomerase B. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.729 |
SEA69844.1 | gcvH | SAMN05421743_10760 | SAMN05421743_11573 | Ribose 5-phosphate isomerase B. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.639 |
SEA69844.1 | gcvPB | SAMN05421743_10760 | SAMN05421743_11832 | Ribose 5-phosphate isomerase B. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.683 |
SEA69844.1 | gcvT | SAMN05421743_10760 | SAMN05421743_11830 | Ribose 5-phosphate isomerase B. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.674 |
SEA69844.1 | glyA | SAMN05421743_10760 | SAMN05421743_10758 | Ribose 5-phosphate isomerase B. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |
SEA69844.1 | purN | SAMN05421743_10760 | SAMN05421743_11032 | Ribose 5-phosphate isomerase B. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.661 |
SEA69844.1 | upp | SAMN05421743_10760 | SAMN05421743_10757 | Ribose 5-phosphate isomerase B. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.940 |
fhs | SEA69844.1 | SAMN05421743_106178 | SAMN05421743_10760 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Ribose 5-phosphate isomerase B. | 0.678 |
fhs | folD | SAMN05421743_106178 | SAMN05421743_11855 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.981 |
fhs | gcvH | SAMN05421743_106178 | SAMN05421743_11573 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.461 |
fhs | gcvPB | SAMN05421743_106178 | SAMN05421743_11832 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.814 |
fhs | gcvT | SAMN05421743_106178 | SAMN05421743_11830 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.806 |
fhs | glyA | SAMN05421743_106178 | SAMN05421743_10758 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
fhs | purD | SAMN05421743_106178 | SAMN05421743_11030 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.895 |
fhs | purH | SAMN05421743_106178 | SAMN05421743_11031 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.946 |
fhs | purN | SAMN05421743_106178 | SAMN05421743_11032 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
folD | SEA69844.1 | SAMN05421743_11855 | SAMN05421743_10760 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Ribose 5-phosphate isomerase B. | 0.729 |
folD | fhs | SAMN05421743_11855 | SAMN05421743_106178 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.981 |
folD | gcvH | SAMN05421743_11855 | SAMN05421743_11573 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.833 |