node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SKB35619.1 | SKB37292.1 | SAMN05661099_0836 | SAMN05661099_0945 | Dihydrolipoamide dehydrogenase. | Glutamate synthase (NADPH/NADH) large chain. | 0.900 |
SKB35619.1 | SKB72944.1 | SAMN05661099_0836 | SAMN05661099_2447 | Dihydrolipoamide dehydrogenase. | Glycine/D-amino acid oxidase. | 0.526 |
SKB35619.1 | SKB82988.1 | SAMN05661099_0836 | SAMN05661099_2983 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.893 |
SKB35619.1 | gcvH | SAMN05661099_0836 | SAMN05661099_2773 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.954 |
SKB35619.1 | gcvP | SAMN05661099_0836 | SAMN05661099_1854 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.962 |
SKB35619.1 | gcvT | SAMN05661099_0836 | SAMN05661099_2801 | Dihydrolipoamide dehydrogenase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.939 |
SKB35619.1 | glyA | SAMN05661099_0836 | SAMN05661099_2753 | Dihydrolipoamide dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
SKB37292.1 | SKB35619.1 | SAMN05661099_0945 | SAMN05661099_0836 | Glutamate synthase (NADPH/NADH) large chain. | Dihydrolipoamide dehydrogenase. | 0.900 |
SKB37292.1 | SKB72944.1 | SAMN05661099_0945 | SAMN05661099_2447 | Glutamate synthase (NADPH/NADH) large chain. | Glycine/D-amino acid oxidase. | 0.960 |
SKB37292.1 | SKB80648.1 | SAMN05661099_0945 | SAMN05661099_2813 | Glutamate synthase (NADPH/NADH) large chain. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.417 |
SKB37292.1 | SKB82988.1 | SAMN05661099_0945 | SAMN05661099_2983 | Glutamate synthase (NADPH/NADH) large chain. | Dihydrolipoamide dehydrogenase. | 0.900 |
SKB37292.1 | gcvH | SAMN05661099_0945 | SAMN05661099_2773 | Glutamate synthase (NADPH/NADH) large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.935 |
SKB37292.1 | gcvP | SAMN05661099_0945 | SAMN05661099_1854 | Glutamate synthase (NADPH/NADH) large chain. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.951 |
SKB37292.1 | gcvT | SAMN05661099_0945 | SAMN05661099_2801 | Glutamate synthase (NADPH/NADH) large chain. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.946 |
SKB37292.1 | glyA | SAMN05661099_0945 | SAMN05661099_2753 | Glutamate synthase (NADPH/NADH) large chain. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
SKB37292.1 | purH | SAMN05661099_0945 | SAMN05661099_1552 | Glutamate synthase (NADPH/NADH) large chain. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.933 |
SKB72944.1 | SKB35619.1 | SAMN05661099_2447 | SAMN05661099_0836 | Glycine/D-amino acid oxidase. | Dihydrolipoamide dehydrogenase. | 0.526 |
SKB72944.1 | SKB37292.1 | SAMN05661099_2447 | SAMN05661099_0945 | Glycine/D-amino acid oxidase. | Glutamate synthase (NADPH/NADH) large chain. | 0.960 |
SKB72944.1 | SKB80648.1 | SAMN05661099_2447 | SAMN05661099_2813 | Glycine/D-amino acid oxidase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.692 |
SKB72944.1 | SKB82988.1 | SAMN05661099_2447 | SAMN05661099_2983 | Glycine/D-amino acid oxidase. | Dihydrolipoamide dehydrogenase. | 0.526 |