STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TVAG_038970tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. (378 aa)    
Predicted Functional Partners:
TVAG_180560
Kelch motif family protein.
  
 
 0.952
TVAG_275350
Kelch motif family protein.
  
 
 0.952
TVAG_086280
Kelch motif family protein.
  
 
 0.952
TVAG_380400
SAM-dependent MTase TRM10-type domain-containing protein.
   
  
 0.899
TVAG_306010
Uncharacterized protein.
   
 
 0.845
TVAG_317290
Uncharacterized protein.
   
 
 0.845
TVAG_185400
Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
   
  
 0.833
TVAG_447890
Cytidine and deoxycytidylate deaminase zinc-binding region family protein.
   
  
 0.824
TVAG_028740
Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.
  
  
 0.820
TVAG_172870
WD_REPEATS_REGION domain-containing protein.
   
  
 0.818
Your Current Organism:
Trichomonas vaginalis
NCBI taxonomy Id: 5722
Other names: T. vaginalis, Tritrichomonas vaginalis
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