node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
appA | fre | HDEF_2244 | HDEF_2108 | Bifunctional: phytase; phosphoanhydride phosphorylase (pH 2.5 acid phosphatase). | Flavin reductase; Preferred substrate is FAD; COG0543. | 0.900 |
appA | ribC | HDEF_2244 | HDEF_0623 | Bifunctional: phytase; phosphoanhydride phosphorylase (pH 2.5 acid phosphatase). | Riboflavin synthase, alpha subunit; COG0307. | 0.900 |
appA | ribF | HDEF_2244 | HDEF_0830 | Bifunctional: phytase; phosphoanhydride phosphorylase (pH 2.5 acid phosphatase). | Bifunctional: flavokinase; COG0196; Belongs to the ribF family. | 0.900 |
cmk | ispH | HDEF_0695 | HDEF_0834 | Cytidine monophosphate (CMP) kinase; COG0283. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. | 0.893 |
cmk | ribF | HDEF_0695 | HDEF_0830 | Cytidine monophosphate (CMP) kinase; COG0283. | Bifunctional: flavokinase; COG0196; Belongs to the ribF family. | 0.787 |
fre | appA | HDEF_2108 | HDEF_2244 | Flavin reductase; Preferred substrate is FAD; COG0543. | Bifunctional: phytase; phosphoanhydride phosphorylase (pH 2.5 acid phosphatase). | 0.900 |
fre | ribC | HDEF_2108 | HDEF_0623 | Flavin reductase; Preferred substrate is FAD; COG0543. | Riboflavin synthase, alpha subunit; COG0307. | 0.900 |
fre | ribF | HDEF_2108 | HDEF_0830 | Flavin reductase; Preferred substrate is FAD; COG0543. | Bifunctional: flavokinase; COG0196; Belongs to the ribF family. | 0.905 |
ileS | ispH | HDEF_0831 | HDEF_0834 | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. | 0.802 |
ileS | lspA | HDEF_0831 | HDEF_0832 | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Prolipoprotein signal peptidase (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.896 |
ileS | ribF | HDEF_0831 | HDEF_0830 | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Bifunctional: flavokinase; COG0196; Belongs to the ribF family. | 0.736 |
ispH | cmk | HDEF_0834 | HDEF_0695 | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. | Cytidine monophosphate (CMP) kinase; COG0283. | 0.893 |
ispH | ileS | HDEF_0834 | HDEF_0831 | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.802 |
ispH | lspA | HDEF_0834 | HDEF_0832 | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. | Prolipoprotein signal peptidase (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.850 |
ispH | ribF | HDEF_0834 | HDEF_0830 | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. | Bifunctional: flavokinase; COG0196; Belongs to the ribF family. | 0.753 |
lspA | ileS | HDEF_0832 | HDEF_0831 | Prolipoprotein signal peptidase (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.896 |
lspA | ispH | HDEF_0832 | HDEF_0834 | Prolipoprotein signal peptidase (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. | 0.850 |
lspA | ribF | HDEF_0832 | HDEF_0830 | Prolipoprotein signal peptidase (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Bifunctional: flavokinase; COG0196; Belongs to the ribF family. | 0.768 |
mviN | ribF | HDEF_0640 | HDEF_0830 | Putative virulence factor; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | Bifunctional: flavokinase; COG0196; Belongs to the ribF family. | 0.845 |
ribC | appA | HDEF_0623 | HDEF_2244 | Riboflavin synthase, alpha subunit; COG0307. | Bifunctional: phytase; phosphoanhydride phosphorylase (pH 2.5 acid phosphatase). | 0.900 |