node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HDEF_2010 | mnmE | HDEF_2010 | HDEF_2008 | Conserved hypothetical phage protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.570 |
HDEF_2010 | rnpA | HDEF_2010 | HDEF_2011 | Conserved hypothetical phage protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.974 |
HDEF_2010 | rplD | HDEF_2010 | HDEF_1865 | Conserved hypothetical phage protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 50S ribosomal subunit protein L4, regulates expression of S10 operon; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.550 |
HDEF_2010 | rpmH | HDEF_2010 | HDEF_2012 | Conserved hypothetical phage protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 50S ribosomal subunit protein L34; COG0230; Belongs to the bacterial ribosomal protein bL34 family. | 0.807 |
HDEF_2010 | yidC | HDEF_2010 | HDEF_2009 | Conserved hypothetical phage protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.954 |
mnmE | HDEF_2010 | HDEF_2008 | HDEF_2010 | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | Conserved hypothetical phage protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.570 |
mnmE | rnpA | HDEF_2008 | HDEF_2011 | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.752 |
mnmE | rplC | HDEF_2008 | HDEF_1866 | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 50S ribosomal subunit protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.690 |
mnmE | rplU | HDEF_2008 | HDEF_2333 | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 50S ribosomal subunit protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.726 |
mnmE | rpmH | HDEF_2008 | HDEF_2012 | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 50S ribosomal subunit protein L34; COG0230; Belongs to the bacterial ribosomal protein bL34 family. | 0.682 |
mnmE | yidC | HDEF_2008 | HDEF_2009 | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.838 |
rnpA | HDEF_2010 | HDEF_2011 | HDEF_2010 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Conserved hypothetical phage protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.974 |
rnpA | mnmE | HDEF_2011 | HDEF_2008 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | GTPase involved in tRNA modification and in thiophene and furan oxidation; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.752 |
rnpA | rplC | HDEF_2011 | HDEF_1866 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 50S ribosomal subunit protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.819 |
rnpA | rplD | HDEF_2011 | HDEF_1865 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 50S ribosomal subunit protein L4, regulates expression of S10 operon; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.798 |
rnpA | rplU | HDEF_2011 | HDEF_2333 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 50S ribosomal subunit protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.749 |
rnpA | rpmH | HDEF_2011 | HDEF_2012 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 50S ribosomal subunit protein L34; COG0230; Belongs to the bacterial ribosomal protein bL34 family. | 0.982 |
rnpA | rpsJ | HDEF_2011 | HDEF_1867 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 30S ribosomal subunit protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | 0.763 |
rnpA | rpsL | HDEF_2011 | HDEF_0721 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 30S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy. | 0.762 |
rnpA | rpsT | HDEF_2011 | HDEF_0369 | RNase P, protein C5 component, processes tRNA, 4.5S RNA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 30S ribosomal subunit protein S20; Binds directly to 16S ribosomal RNA. | 0.763 |