STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hel308DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (763 aa)    
Predicted Functional Partners:
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
  
 0.984
flpA
Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
   
 0.905
Vdis_2428
Like-Sm ribonucleoprotein core; COGs: COG1958 Small nuclear ribonucleoprotein (snRNP) homolog; InterPro IPR006649:IPR010920:IPR001163; KEGG: cma:Cmaq_1529 like-Sm ribonucleoprotein core; PFAM: Like-Sm ribonucleoprotein core; SMART: Sm-family ribonucleoprotein; SPTR: A8M9D3 Like-Sm ribonucleoprotein core; PFAM: LSM domain.
  
 0.864
Vdis_0080
COGs: COG1958 Small nuclear ribonucleoprotein (snRNP) homolog; InterPro IPR010920:IPR006649:IPR001163; KEGG: tne:Tneu_1974 like-Sm ribonucleoprotein core; PFAM: Like-Sm ribonucleoprotein core; SMART: Sm-family ribonucleoprotein; SPTR: B1YC35 Like-Sm ribonucleoprotein core; PFAM: LSM domain.
  
 0.862
Vdis_1863
Like-Sm ribonucleoprotein core; InterPro IPR006649:IPR001163:IPR010920; KEGG: cma:Cmaq_0025 like-Sm ribonucleoprotein core; PFAM: Like-Sm ribonucleoprotein core; SMART: Sm-family ribonucleoprotein; SPTR: A8M9J8 Like-Sm ribonucleoprotein core; PFAM: LSM domain; Gemin6 protein.
  
 0.862
rpl7ae
Ribosomal protein L7Ae/L30e/S12e/Gadd45; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
 
 0.810
Vdis_2413
Peptidase S9 prolyl oligopeptidase active site domain protein; COGs: COG1506 Dipeptidyl aminopeptidase/acylaminoacyl-peptidase; InterPro IPR011042:IPR001375; KEGG: pab:PAB1300 acyl-peptide hydrolase; PFAM: peptidase S9 prolyl oligopeptidase active site domain protein; SPTR: Q9UYB0 ApeH acylamino-acid-releasing enzyme (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase); PFAM: Prolyl oligopeptidase family.
    
 0.676
Vdis_0530
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: siy:YG5714_2221 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: D0KR81 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase.
   
   0.634
Vdis_0532
Nucleotidyl transferase; COGs: COG1209 dTDP-glucose pyrophosphorylase; InterPro IPR005835; KEGG: sai:Saci_0422 nucleotidyl transferase; PFAM: Nucleotidyl transferase; SPTR: Q4JBJ4 Nucleotidyl transferase; PFAM: Nucleotidyl transferase.
       0.615
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
   
   0.575
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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