STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Vdis_0616GMP synthase, small subunit; COGs: COG0518 GMP synthase - Glutamine amidotransferase domain; InterProIPR011702:IPR006220:IPR001317:IPR000991:IPR 004739:IPR017926; KEGG: cma:Cmaq_1203 glutamine amidotransferase class-I; PFAM: glutamine amidotransferase class-I; SPTR: A8ME24 Glutamine amidotransferase class-I; TIGRFAM: GMP synthase, small subunit; PFAM: Glutamine amidotransferase class-I; TIGRFAM: GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit. (189 aa)    
Predicted Functional Partners:
Vdis_0615
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterPro IPR000209:IPR003694:IPR001674:IPR014729; KEGG: cma:Cmaq_1202 GMP synthase domain-containing protein; PFAM: GMP synthase domain protein; NAD synthase; PRIAM: GMP synthase (glutamine-hydrolyzing); SPTR: A8ME23 GMP synthase domain protein; PFAM: GMP synthase C terminal domain; PP-loop family; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit.
  
 0.999
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.954
Vdis_0676
Phosphoribosyltransferase; COGs: COG0503 Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; InterPro IPR000836; KEGG: kcr:Kcr_0396 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: B1L3X3 Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain.
  
 
 0.949
Vdis_0922
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; COGs: COG0127 Xanthosine triphosphate pyrophosphatase; InterPro IPR002637; KEGG: cma:Cmaq_1974 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; PFAM: Ham1 family protein; SPTR: A8MC06 Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; PFAM: Ham1 family; TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Belongs to the HAM1 NTPase family.
 
 
 0.947
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
  
 0.917
Vdis_0579
COGs: COG0151 Phosphoribosylamine-glycine ligase; InterProIPR016185:IPR011054:IPR020562:IPR020561:IPR 020560:IPR000115:IPR011761:IPR013817:IPR013816; KEGG: cma:Cmaq_0663 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: A8MCJ7 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synt [...]
 
  
 0.821
Vdis_2131
COGs: COG0015 Adenylosuccinate lyase; InterProIPR000362:IPR013539:IPR020557:IPR003031:IPR 008948; KEGG: cma:Cmaq_0020 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A8M9J3 Adenylosuccinate lyase domain protein; PFAM: Lyase; Adenylosuccinate lyase C-terminal.
 
  
 0.802
map
Methionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
  
    0.794
Vdis_2456
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
  
 0.775
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
     
 0.772
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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