STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Vdis_1325Protein of unknown function DUF650; Involved in DNA damage repair. (413 aa)    
Predicted Functional Partners:
Vdis_1326
Radical SAM domain protein; COGs: COG1533 DNA repair photolyase; InterPro IPR007197; KEGG: cma:Cmaq_1829 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: A8MB17 Radical SAM domain protein; PFAM: Radical SAM superfamily.
       0.821
ribK
CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
  
     0.669
Vdis_0819
COGs: COG0704 Phosphate uptake regulator; InterPro IPR007159:IPR008170; KEGG: cma:Cmaq_0447 phosphate uptake regulator, PhoU; PFAM: PhoU family protein; SpoVT/AbrB domain protein; SPTR: A8MBU9 Phosphate uptake regulator, PhoU; PFAM: PhoU domain; SpoVT / AbrB like domain.
 
     0.646
Vdis_1327
KEGG: sid:M164_0721 hypothetical protein; SPTR: C4KFC2 Putative uncharacterized protein.
       0.610
vapC
PilT protein domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.
       0.610
Vdis_0240
COGs: COG0704 Phosphate uptake regulator; InterPro IPR007159:IPR008170; KEGG: cma:Cmaq_0595 phosphate uptake regulator, PhoU; PFAM: PhoU family protein; SpoVT/AbrB domain protein; SPTR: A8MCD0 Phosphate uptake regulator, PhoU; PFAM: PhoU domain; SpoVT / AbrB like domain; TIGRFAM: looped-hinge helix DNA binding domain, AbrB family.
 
     0.608
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
 
     0.606
Vdis_0002
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
  
     0.600
priS
DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
 
     0.575
Vdis_0540
Protein of unknown function DUF655; COGs: COG1491 RNA-binding protein; InterPro IPR007003; KEGG: cma:Cmaq_1981 hypothetical protein; PFAM: Protein of unknown function DUF655; SPTR: A8MC13 Putative uncharacterized protein; PFAM: Protein of unknown function, DUF655.
 
     0.549
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.