STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Vdis_1664Isochorismatase hydrolase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: cma:Cmaq_1336 isochorismatase hydrolase; PFAM: isochorismatase hydrolase; SPTR: A8M8U3 Isochorismatase hydrolase; PFAM: Isochorismatase family. (224 aa)    
Predicted Functional Partners:
Vdis_1665
KEGG: cma:Cmaq_0091 hypothetical protein; SPTR: A8M9R4 Putative uncharacterized protein.
       0.773
Vdis_2534
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638:IPR007229; KEGG: cma:Cmaq_0933 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; SPTR: A8MDA9 Quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: putative nicotinate phosphoribosyltransferase.
 
  
 0.656
Vdis_2437
Isochorismatase hydrolase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: cma:Cmaq_1023 isochorismatase hydrolase; PFAM: isochorismatase hydrolase; SPTR: A8MDJ8 Isochorismatase hydrolase; PFAM: Isochorismatase family.
  
     0.580
Vdis_1666
COGs: COG1257 Hydroxymethylglutaryl-CoA reductase; InterPro IPR002202:IPR009029:IPR009023:IPR004554; KEGG: pas:Pars_0796 3-hydroxy-3-methylglutaryl coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; SPTR: A4WJ15 3-hydroxy-3-methylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); Belongs to the HMG-CoA reductase family.
     
 0.536
Vdis_1662
Hypothetical protein; InterPro IPR005242; KEGG: mmq:MmarC5_1628 hypothetical protein; SPTR: A4G0E1 Putative uncharacterized protein; PFAM: Uncharacterised protein family (UPF0104); TIGRFAM: conserved hypothetical protein.
  
    0.495
Vdis_1663
KEGG: bba:Bd1959 hypothetical protein; SPTR: C9ZQA9 Helicase, putative.
       0.488
Vdis_1667
COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR002155:IPR016038:IPR016039; KEGG: cma:Cmaq_1242 acetyl-CoA C-acyltransferase; SPTR: A8ME63 Acetyl-CoA C-acyltransferase; PFAM: Thiolase, C-terminal domain.
  
   0.444
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
 
 
 0.431
Vdis_1914
Precorrin-8X methylmutase CbiC/CobH; COGs: COG2082 Precorrin isomerase; InterPro IPR003722:IPR002762; KEGG: sto:ST1824 bifunctional sirohydrochlorin cobalt chelatase/precorrin-8X methylmutase; PFAM: Precorrin-8X methylmutase CbiC/CobH; cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Q96ZL1 333aa long hypothetical precorrin-8x methylmutase; PFAM: Precorrin-8X methylmutase; CbiX.
       0.428
Vdis_2483
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
 
 0.423
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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