STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (331 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
  
 
 0.999
Vdis_1697
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
 
 
 0.981
Vdis_1144
Protein of unknown function DUF911 endonuclease; COGs: COG4343 conserved hypothetical protein; InterPro IPR009260; KEGG: hbu:Hbut_0651 hypothetical protein; PFAM: Protein of unknown function DUF911 endonuclease-like; SPTR: A2BKJ7 Conserved archaeal protein; PFAM: Archaeal protein of unknown function (DUF911); TIGRFAM: CRISPR-associated protein, Csa1 family.
   
 
 0.945
Vdis_1700
CRISPR-associated protein, Csa1 family; COGs: COG4343 conserved hypothetical protein; InterPro IPR009260; KEGG: ape:APE_1241.1 putative CRISPR-associated protein; PFAM: Protein of unknown function DUF911 endonuclease-like; SPTR: Q9YCL7 Putative CRISPR-associated protein; TIGRFAM: CRISPR-associated protein, Csa1 family; PFAM: Archaeal protein of unknown function (DUF911); TIGRFAM: CRISPR-associated protein, Csa1 family.
 
   
 0.916
Vdis_1690
Helicase domain protein; COGs: COG1203 helicase; InterProIPR011545:IPR001650:IPR013838:IPR014021:IPR 014001; KEGG: cma:Cmaq_1525 CRISPR-associated helicase Cas3; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: helicase domain protein; DEAD-like helicase; SPTR: A8M9D0 CRISPR-associated helicase Cas3; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3.
 
  
 0.794
Vdis_1163
CRISPR-associated RAMP protein, Cmr4 family; COGs: COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR013410:IPR005537; KEGG: cma:Cmaq_1517 CRISPR-associated RAMP Cmr4 family protein family protein; PFAM: protein of unknown function DUF324; SPTR: A8M9C2 CRISPR-associated RAMP protein, Cmr4 family; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; PFAM: RAMP superfamily; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family.
 
   
 0.747
Vdis_2197
Hypothetical protein; KEGG: cag:Cagg_0565 CRISPR-associated protein Cas4; SPTR: Q50I54 Putative uncharacterized protein; PFAM: Domain of unknown function DUF83.
   
 
 0.735
Vdis_2540
KEGG: Hypothetical protein CBG13617; SPTR: B6EFB5 Putative uncharacterized protein.
   
 
 0.735
Vdis_0790
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104:IPR016040; KEGG: cma:Cmaq_0906 oxidoreductase domain-containing protein; PFAM: oxidoreductase domain protein; Oxidoreductase domain; SPTR: A8MD83 Oxidoreductase domain protein; PFAM: Oxidoreductase family, NAD-binding Rossmann fold.
  
 
 0.582
Vdis_1502
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104:IPR016040; KEGG: sso:SSO3013 dehydrogenase, putative; PFAM: oxidoreductase domain protein; Oxidoreductase domain; SPTR: Q97UJ8 Dehydrogenase, putative; PFAM: Oxidoreductase family, C-terminal alpha/beta domain; Oxidoreductase family, NAD-binding Rossmann fold.
  
 
 0.582
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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