STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Vdis_2268Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (895 aa)    
Predicted Functional Partners:
tmk
COGs: COG0125 Thymidylate kinase; InterPro IPR018095:IPR000062:IPR018094; KEGG: cma:Cmaq_0300 dTMP kinase; PFAM: thymidylate kinase; PRIAM: dTMP kinase; SPTR: A8MB58 Probable thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase.
  
 
 0.937
Vdis_2035
COGs: COG0105 Nucleoside diphosphate kinase; InterPro IPR001564; KEGG: tne:Tneu_0651 nucleoside-diphosphate kinase; PFAM: nucleoside diphosphate kinase; PRIAM: Nucleoside-diphosphate kinase; SMART: nucleoside diphosphate kinase; SPTR: B1YCS7 Nucleoside diphosphate kinase; PFAM: Nucleoside diphosphate kinase.
    
 0.933
adkA
COGs: COG2019 adenylate kinase; KEGG: cma:Cmaq_0378 adenylate kinase; PRIAM: Adenylate kinase; SPTR: A8MBD4 Adenylate kinase; Belongs to the archaeal adenylate kinase family.
  
  
  0.918
Vdis_0717
COGs: COG0469 Pyruvate kinase; InterProIPR015793:IPR015794:IPR015813:IPR015795:IPR 011037:IPR001697; KEGG: cma:Cmaq_0580 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: A8MCB5 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
    
 0.916
Vdis_1475
Conserved hypothetical protein; COGs: COG1936 nucleotide kinase (related to CMP and AMP kinase); KEGG: tpe:Tpen_0444 hypothetical protein; SPTR: A1RXC3 Putative uncharacterized protein; PFAM: Shikimate kinase.
   
 
  0.908
cmk
COGs: COG1102 Cytidylate kinase; InterPro IPR000623:IPR011892; KEGG: cma:Cmaq_0898 cytidylate kinase; PFAM: shikimate kinase; PRIAM: Cytidylate kinase; SPTR: A8MD76 Cytidylate kinase, putative; TIGRFAM: cytidylate kinase; PFAM: Shikimate kinase; TIGRFAM: cytidylate kinase, putative.
    
  0.907
Vdis_0241
Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
  0.900
Vdis_0520
MCM family protein; COGs: COG1241 ATPase involved in replication control Cdc46/Mcm family; InterPro IPR016027:IPR001208:IPR012340; KEGG: cma:Cmaq_0382 MCM family protein; PFAM: MCM family protein; SMART: MCM family protein; SPTR: A8MBD8 MCM family protein; PFAM: MCM2/3/5 family; Belongs to the MCM family.
  
  
 0.882
Vdis_1982
KEGG: sin:YN1551_1004 hypothetical protein; SPTR: C4KIP1 Putative uncharacterized protein.
  
  
 0.771
Vdis_0725
Thioredoxin; COGs: COG3118 Thioredoxin domain-containing protein; InterProIPR017936:IPR013766:IPR006662:IPR012336:IPR 012335:IPR005746; KEGG: afu:AF1284 thioredoxin (trx-3); PFAM: Thioredoxin domain; SPTR: O28984 Thioredoxin (Trx-3); TIGRFAM: thioredoxin; PFAM: Thioredoxin; TIGRFAM: thioredoxin.
  
 
 0.756
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.