STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Vdis_2324COGs: COG0864 transcriptional regulator protein containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain; InterPro IPR013321:IPR014864; KEGG: pis:Pisl_0193 CopG family transcriptional regulator; PFAM: NikR nickel binding; SPTR: A1RQZ3 Transcriptional regulator, CopG family; PFAM: NikR C terminal nickel binding domain; TIGRFAM: nickel-responsive transcriptional regulator NikR. (138 aa)    
Predicted Functional Partners:
Vdis_0220
Transketolase central region; COGs: COG3958 Transketolase C-terminal subunit; InterProIPR009014:IPR015941:IPR005474:IPR005475:IPR 005476; KEGG: cma:Cmaq_0809 transketolase central region; PFAM: Transketolase central region; Transketolase domain protein; SPTR: A8MCY8 Transketolase central region; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; TIGRFAM: 1-deoxy-D-xylulose-5-phosphate synthase.
       0.605
Vdis_2323
PaREP1 family protein; InterPro IPR010268; KEGG: cma:Cmaq_0294 PaREP1 protein; PFAM: PaREP1 family protein; SPTR: A8MAV6 PaREP1 protein; PFAM: Archaeal PaREP1/PaREP8 family.
       0.601
Vdis_2322
Protein of unknown function DUF364; COGs: COG2014 conserved hypothetical protein; InterPro IPR007161; KEGG: pas:Pars_1281 hypothetical protein; PFAM: protein of unknown function DUF364; SPTR: A4WKC8 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF364).
       0.546
hypA
Hydrogenase expression/synthesis HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.521
Vdis_2115
GHMP kinase; COGs: COG0153 Galactokinase; InterProIPR000705:IPR014721:IPR019539:IPR006204:IPR 013750:IPR006203:IPR006206:IPR020568; KEGG: dka:DKAM_0259 GHMP kinase; PFAM: GHMP kinase; Galactokinase galactose-binding domain; GHMP kinase domain protein; SPTR: B8D2K4 GHMP kinase; PFAM: Galactokinase galactose-binding signature; GHMP kinases C terminal; GHMP kinases N terminal domain.
   
    0.509
Vdis_2308
COGs: COG0374 Ni Fe-hydrogenase I large subunit; InterPro IPR018194:IPR001501; KEGG: pcl:Pcal_1578 nickel-dependent hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: A3MWH9 Nickel-dependent hydrogenase, large subunit; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.488
Vdis_2313
COGs: COG1740 Ni Fe-hydrogenase I small subunit; InterPro IPR001821:IPR006311:IPR017909; KEGG: pcl:Pcal_1575 nickel-dependent hydrogenase small subunit; SPTR: A3MWH6 Nickel-iron dehydrogenase small subunit, N-terminal domain protein; TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: hydrogenase (NiFe) small subunit (hydA); Tat (twin-arginine translocation) pathway signal sequence.
 
   
 0.469
Vdis_2321
COGs: COG3376 High-affinity nickel permease; InterPro IPR011541; KEGG: sis:LS215_0486 high-affinity nickel-transporter; PFAM: high-affinity nickel-transporter; SPTR: C3MLK5 High-affinity nickel-transporter; PFAM: High-affinity nickel-transport protein; TIGRFAM: high-affinity nickel-transporter, HoxN/HupN/NixA family; Belongs to the NiCoT transporter (TC 2.A.52) family.
 
     0.468
Vdis_0884
AMMECR1 domain protein; COGs: COG2078 conserved hypothetical protein; InterPro IPR002733; KEGG: cma:Cmaq_0319 AMMECR1 domain-containing protein; PFAM: AMMECR1 domain protein; SPTR: A8MB77 AMMECR1 domain protein; PFAM: AMMECR1; TIGRFAM: conserved hypothetical protein TIGR00296.
 
     0.466
Vdis_2316
Hydrogenase formation HypD protein; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: pis:Pisl_0205 hydrogenase formation HypD protein; PFAM: hydrogenase formation HypD protein; SPTR: A1RR05 Hydrogenase formation HypD protein; PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD.
 
     0.455
Your Current Organism:
Vulcanisaeta distributa
NCBI taxonomy Id: 572478
Other names: V. distributa DSM 14429, Vulcanisaeta distributa DSM 14429, Vulcanisaeta distributa str. DSM 14429, Vulcanisaeta distributa strain DSM 14429
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