STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (147 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the thymidine kinase family.
  
 
 0.968
ADO82951.1
Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
  
 0.958
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.951
ADO83639.1
CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR016473:IPR016193:IPR002125:IPR016192; KEGG: fnu:FN1902 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: C6JMP4 Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region.
  
 0.942
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
 0.941
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.906
ADO81825.1
5'-Nucleotidase domain protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterProIPR008334:IPR004843:IPR018392:IPR002482:IPR 006179; KEGG: cdl:CDR20291_2424 putative membrane-associated 5'-nucleotidase/phosphoesterase; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding LysM; SPTR: C6JPY3 5'-Nucleotidase domain-containing protein; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; LysM domain; Belongs to the 5'-nucleotidase family.
    
  0.900
ADO82915.1
Transposase-like Mu; InterPro IPR009057:IPR015378; KEGG: sah:SaurJH1_2822 integrase catalytic region; PFAM: Transposase-like Mu; SPTR: C6JPV3 Predicted protein; PFAM: Mu transposase, C-terminal.
    
 0.852
ADO82158.1
Peptidase M16 domain protein; COGs: COG0612 Zn-dependent peptidase; InterProIPR011249:IPR011765:IPR007863:IPR001431:IPR 011237; KEGG: fnu:FN1029 zinc protease; PFAM: peptidase M16 domain protein; SPTR: C6JNL6 Zinc protease; PFAM: Peptidase M16 inactive domain; Insulinase (Peptidase family M16); Belongs to the peptidase M16 family.
       0.776
ADO82917.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
  
 0.730
Your Current Organism:
Ilyobacter polytropus
NCBI taxonomy Id: 572544
Other names: I. polytropus DSM 2926, Ilyobacter polytropus DSM 2926, Ilyobacter polytropus str. DSM 2926, Ilyobacter polytropus strain DSM 2926
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