STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADO82269.1Iron-only hydrogenase maturation protein HydG; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR006638:IPR007197:IPR010722:IPR013785; KEGG: kol:Kole_0394 biotin and thiamin synthesis associated; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: C4BVD1 Iron-only hydrogenase maturation protein HydG; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (471 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.978
ADO82243.1
Iron-only hydrogenase maturation protein HydF; COGs: COG1160 GTPase; InterPro IPR002917:IPR005225; KEGG: tpd:Teth39_0245 small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; SPTR: C4BVH2 Iron-only hydrogenase maturation protein HydF; TIGRFAM: small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
  
 0.921
ADO82965.1
Tyrosine lyase ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR012726:IPR013785:IPR007197:IPR010722; KEGG: cpf:CPF_1853 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: C3WE28 Thiazole biosynthesis protein ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH.
  
  
 
0.920
ADO82268.1
KEGG: cpf:CPF_0107 hypothetical protein; SPTR: Q93SG3 Putative uncharacterized protein.
 
   
 0.807
ADO82270.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.773
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.661
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.632
ADO83002.1
NAD(P)-dependent iron-only hydrogenase catalytic subunit; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR017900:IPR013352:IPR009016:IPR001041:IPR 003149:IPR019574:IPR001450:IPR004108:IPR017896; KEGG: tau:Tola_1506 hydrogenase, Fe-only; PFAM: hydrogenase large subunit domain protein; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; iron hydrogenase small subunit; SPTR: C4LEV1 Hydrogenase, Fe-only; TIGRFAM: hydrogenase, Fe-only; PFAM: 2Fe-2S iron-sulfur cluster binding domai [...]
 
   
 0.624
ADO82476.1
NAD(P)-dependent iron-only hydrogenase catalytic subunit; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR001041:IPR019574:IPR001450:IPR004108:IPR 003149:IPR017900:IPR017896:IPR013352:IPR009016; KEGG: pca:Pcar_1605 NAD-reducing iron-only hydrogenase large subunit; PFAM: hydrogenase large subunit domain protein; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; iron hydrogenase small subunit; SPTR: C4ESV4 Hydrogenase, Fe-only; TIGRFAM: hydrogenase, Fe-only; PFAM: 2Fe-2S iron- [...]
 
   
 0.613
ADO83164.1
Anti-sigma-factor antagonist; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR003658:IPR002645; KEGG: fnu:FN1914 anti-sigma F factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: C6JJP8 Anti-sigma factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; Belongs to the anti-sigma-factor antagonist family.
  
    0.599
Your Current Organism:
Ilyobacter polytropus
NCBI taxonomy Id: 572544
Other names: I. polytropus DSM 2926, Ilyobacter polytropus DSM 2926, Ilyobacter polytropus str. DSM 2926, Ilyobacter polytropus strain DSM 2926
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