Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADB57088.1TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: sat:SYN_01979 anaerobic ribonucleoside- triphosphate reductase. (695 aa)    
Predicted Functional Partners:
ADB58336.1
KEGG: sat:SYN_03523 pyruvate formate-lyase activating enzyme; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
  
 0.967
ADB58893.1
PFAM: protein of unknown function UPF0066; KEGG: avn:Avin_38460 hypothetical protein.
    
 0.919
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
     
 0.918
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.911
ADB57287.1
PFAM: protein of unknown function DUF265; KEGG: GE22362 gene product from transcript GE22362- RA.
   
 
  0.909
ADB58894.1
TIGRFAM: adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: dol:Dole_2312 putative adenylyl cyclase CyaB.
     
  0.900
mptA
Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
  
  
  0.835
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
    
 0.819
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
    
  0.802
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.738
Your Current Organism:
Archaeoglobus profundus
NCBI taxonomy Id: 572546
Other names: A. profundus DSM 5631, Archaeoglobus profundus DSM 5631, Archaeoglobus profundus str. DSM 5631, Archaeoglobus profundus strain DSM 5631
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