Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (204 aa)    
Predicted Functional Partners:
ADB58645.1
PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: cff:CFF8240_0969 phosphomethylpyrimidine kinase.
 
 0.999
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
 
 
 0.945
ADB58786.1
TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; KEGG: gbm:Gbem_3463 thiamine biosynthesis protein ThiC.
  
  
 0.920
ADB57287.1
PFAM: protein of unknown function DUF265; KEGG: GE22362 gene product from transcript GE22362- RA.
     
  0.900
ADB57106.1
PFAM: thiamineS protein.
  
  
 0.896
ADB58624.1
KEGG: gme:Gmet_0153 trifunctional NADH dehydrogenase I subunit B/C/D; TIGRFAM: NADH-quinone oxidoreductase, B subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; NADH-ubiquinone oxidoreductase chain 49kDa; NADH dehydrogenase (ubiquinone) 30 kDa subunit.
     
 0.837
ADB57867.1
PFAM: NUDIX hydrolase; KEGG: gur:Gura_1829 NUDIX hydrolase.
     
 0.804
ADB57255.1
PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_0234 radical SAM domain protein.
  
  
 0.701
cofG
Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
  
 0.701
cofH
Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
  
  
 0.701
Your Current Organism:
Archaeoglobus profundus
NCBI taxonomy Id: 572546
Other names: A. profundus DSM 5631, Archaeoglobus profundus DSM 5631, Archaeoglobus profundus str. DSM 5631, Archaeoglobus profundus strain DSM 5631
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