node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEK58343.1 | SEK58362.1 | SAMN05216208_1245 | SAMN05216208_1246 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 0.996 |
SEK58343.1 | SEK77109.1 | SAMN05216208_1245 | SAMN05216208_1992 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.888 |
SEK58343.1 | SEK93884.1 | SAMN05216208_1245 | SAMN05216208_2238 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | Acetolactate synthase, large subunit. | 0.753 |
SEK58343.1 | SEK93910.1 | SAMN05216208_1245 | SAMN05216208_2239 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | Acetolactate synthase, small subunit. | 0.904 |
SEK58343.1 | ilvC | SAMN05216208_1245 | SAMN05216208_1616 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.933 |
SEK58343.1 | ilvD | SAMN05216208_1245 | SAMN05216208_1474 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.926 |
SEK58343.1 | leuA | SAMN05216208_1245 | SAMN05216208_1034 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.903 |
SEK58343.1 | leuB | SAMN05216208_1245 | SAMN05216208_3207 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.960 |
SEK58343.1 | leuC | SAMN05216208_1245 | SAMN05216208_1947 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.934 |
SEK58362.1 | SEK58343.1 | SAMN05216208_1246 | SAMN05216208_1245 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | 0.996 |
SEK58362.1 | SEK77109.1 | SAMN05216208_1246 | SAMN05216208_1992 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.941 |
SEK58362.1 | SEK93884.1 | SAMN05216208_1246 | SAMN05216208_2238 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Acetolactate synthase, large subunit. | 0.789 |
SEK58362.1 | SEK93910.1 | SAMN05216208_1246 | SAMN05216208_2239 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Acetolactate synthase, small subunit. | 0.889 |
SEK58362.1 | ilvC | SAMN05216208_1246 | SAMN05216208_1616 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.949 |
SEK58362.1 | ilvD | SAMN05216208_1246 | SAMN05216208_1474 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.938 |
SEK58362.1 | leuA | SAMN05216208_1246 | SAMN05216208_1034 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.979 |
SEK58362.1 | leuB | SAMN05216208_1246 | SAMN05216208_3207 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.999 |
SEK58362.1 | leuC | SAMN05216208_1246 | SAMN05216208_1947 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.777 |
SEK58362.1 | leuD | SAMN05216208_1246 | SAMN05216208_1949 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.998 |
SEK77109.1 | SEK58343.1 | SAMN05216208_1992 | SAMN05216208_1245 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. | 0.888 |