Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV23875.1PFAM: Transcription factor CBF/NF-Y/histone domain protein; Histone core domain protein. (67 aa)    
Predicted Functional Partners:
cofD
LPPG domain protein containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
     0.751
ACV23872.1
PFAM: Glycosyltransferase 28 domain; KEGG: rhi:NGR_b12360 membrane-anchored protein.
 
     0.642
ACV23871.1
Transcriptional regulator, MarR family; PFAM: regulatory protein MarR; KEGG: viral A-type inclusion protein.
 
     0.592
ACV23874.1
PFAM: THUMP domain protein; ribosomal RNA methyltransferase RrmJ/FtsJ; KEGG: vvy:VV0873 thiamine biosynthesis protein ThiI.
       0.588
ACV23877.1
PFAM: Protein of unknown function DUF2116, Zn-ribbon.
       0.535
thrS
TIGRFAM: threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; KEGG: tgr:Tgr7_1450 threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.532
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
       0.496
albA
DNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family.
  
   
 0.470
atpE
H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
     0.466
secF
SecD/SecF/SecDF export membrane protein; Involved in protein export.
 
     0.465
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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