Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
ACV23885.1PFAM: sodium/hydrogen exchanger; KEGG: fph:Fphi_1574 monovalent cation:proton antiporter family protein. (387 aa)    
Predicted Functional Partners:
ACV24394.1
PFAM: TrkA-N domain protein; Ion transport 2 domain protein; TrkA-C domain protein; KEGG: gem:GM21_3877 TrkA-N domain protein.
  
  
 0.952
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
     
 0.726
ACV24426.1
PFAM: sodium/hydrogen exchanger; KEGG: cja:CJA_2911 putative pH regulated Na(+)/H(+) antiporter.
   
 
 0.667
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
     0.665
ACV24138.1
TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; KEGG: wbr:WGLp587 asparagine synthetase B.
 
  
 0.498
ACV24401.1
KEGG: afr:AFE_0818 plasma-membrane proton-efflux P-type ATPase; TIGRFAM: plasma-membrane proton-efflux P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase type 3.
  
 
 0.491
ACV25046.1
TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: sat:SYN_01009 calcium-transporting ATPase.
  
 
 0.491
ACV24074.1
PFAM: ADP-ribosylation/Crystallin J1; KEGG: dda:Dd703_3606 ADP-ribosylation/crystallin J1.
 
  
 0.483
corA
Magnesium and cobalt transport protein CorA; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
 
  
 0.454
ACV23861.1
PFAM: TrkA-N domain protein; TrkA-C domain protein; KEGG: lip:LI0774 potassium transporter peripheral membrane component.
  
  
 0.427
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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