| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACV23885.1 | dphB | Mefer_0043 | Mefer_0044 | PFAM: sodium/hydrogen exchanger; KEGG: fph:Fphi_1574 monovalent cation:proton antiporter family protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.665 |
| ACV24241.1 | ACV24589.1 | Mefer_0415 | Mefer_0771 | PFAM: Protein of unknown function DUF555; Belongs to the UPF0212 family. | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: Atpbd4; ATP binding domain 4. | 0.602 |
| ACV24241.1 | ACV24706.1 | Mefer_0415 | Mefer_0888 | PFAM: Protein of unknown function DUF555; Belongs to the UPF0212 family. | PFAM: Protein of unknown function DUF357. | 0.609 |
| ACV24241.1 | dphB | Mefer_0415 | Mefer_0044 | PFAM: Protein of unknown function DUF555; Belongs to the UPF0212 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.599 |
| ACV24487.1 | ACV24589.1 | Mefer_0668 | Mefer_0771 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: Atpbd4; ATP binding domain 4. | 0.773 |
| ACV24487.1 | ACV25276.1 | Mefer_0668 | Mefer_1473 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | 0.408 |
| ACV24487.1 | ACV25322.1 | Mefer_0668 | Mefer_1519 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: small GTP-binding protein; PFAM: TGS domain protein; GTP-binding protein HSR1-related; KEGG: hypothetical protein. | 0.487 |
| ACV24487.1 | dphB | Mefer_0668 | Mefer_0044 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.953 |
| ACV24487.1 | fusA | Mefer_0668 | Mefer_1270 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.982 |
| ACV24487.1 | pcn | Mefer_0668 | Mefer_0432 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.759 |
| ACV24487.1 | rpl37ae | Mefer_0668 | Mefer_1378 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L37a; Binds to the 23S rRNA. | 0.717 |
| ACV24589.1 | ACV24241.1 | Mefer_0771 | Mefer_0415 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: Atpbd4; ATP binding domain 4. | PFAM: Protein of unknown function DUF555; Belongs to the UPF0212 family. | 0.602 |
| ACV24589.1 | ACV24487.1 | Mefer_0771 | Mefer_0668 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: Atpbd4; ATP binding domain 4. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.773 |
| ACV24589.1 | dphB | Mefer_0771 | Mefer_0044 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: Atpbd4; ATP binding domain 4. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.846 |
| ACV24589.1 | fusA | Mefer_0771 | Mefer_1270 | TIGRFAM: ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: Atpbd4; ATP binding domain 4. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.942 |
| ACV24706.1 | ACV24241.1 | Mefer_0888 | Mefer_0415 | PFAM: Protein of unknown function DUF357. | PFAM: Protein of unknown function DUF555; Belongs to the UPF0212 family. | 0.609 |
| ACV24706.1 | dphB | Mefer_0888 | Mefer_0044 | PFAM: Protein of unknown function DUF357. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.656 |
| ACV25276.1 | ACV24487.1 | Mefer_1473 | Mefer_0668 | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.408 |
| ACV25276.1 | dphB | Mefer_1473 | Mefer_0044 | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.764 |
| ACV25276.1 | pcn | Mefer_1473 | Mefer_0432 | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.482 |
