| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACV23893.1 | hacB | Mefer_0051 | Mefer_0048 | PFAM: ERCC4 domain protein; helix-hairpin-helix motif; DEAD/DEAH box helicase domain protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; Helix-hairpin-helix DNA-binding class 1; KEGG: hypothetical protein; K10896 fanconi anemia group M protein. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.480 |
| ACV23893.1 | rgy | Mefer_0051 | Mefer_0049 | PFAM: ERCC4 domain protein; helix-hairpin-helix motif; DEAD/DEAH box helicase domain protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; Helix-hairpin-helix DNA-binding class 1; KEGG: hypothetical protein; K10896 fanconi anemia group M protein. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.520 |
| ACV23893.1 | taw3 | Mefer_0051 | Mefer_0050 | PFAM: ERCC4 domain protein; helix-hairpin-helix motif; DEAD/DEAH box helicase domain protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; Helix-hairpin-helix DNA-binding class 1; KEGG: hypothetical protein; K10896 fanconi anemia group M protein. | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.766 |
| ACV24185.1 | ACV25342.1 | Mefer_0350 | Mefer_1539 | TIGRFAM: DNA helicase; SMART: DEAD-like helicase; KEGG: nam:NAMH_1081 putative DNA helicase. | TIGRFAM: L-seryl-tRNA(Sec) kinase; PFAM: Chromatin associated protein KTI12; KEGG: hypothetical protein. | 0.416 |
| ACV24185.1 | taw3 | Mefer_0350 | Mefer_0050 | TIGRFAM: DNA helicase; SMART: DEAD-like helicase; KEGG: nam:NAMH_1081 putative DNA helicase. | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.658 |
| ACV24478.1 | taw3 | Mefer_0659 | Mefer_0050 | PFAM: PilT protein domain protein; Protein of unknown function DUF652; SMART: Nucleotide binding protein PINc; KEGG: similar to RE14259p. | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.495 |
| ACV25276.1 | endA | Mefer_1473 | Mefer_1397 | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.447 |
| ACV25276.1 | taw1 | Mefer_1473 | Mefer_0099 | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | Wyosine base formation domain protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). | 0.706 |
| ACV25276.1 | taw3 | Mefer_1473 | Mefer_0050 | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.678 |
| ACV25342.1 | ACV24185.1 | Mefer_1539 | Mefer_0350 | TIGRFAM: L-seryl-tRNA(Sec) kinase; PFAM: Chromatin associated protein KTI12; KEGG: hypothetical protein. | TIGRFAM: DNA helicase; SMART: DEAD-like helicase; KEGG: nam:NAMH_1081 putative DNA helicase. | 0.416 |
| ACV25342.1 | taw3 | Mefer_1539 | Mefer_0050 | TIGRFAM: L-seryl-tRNA(Sec) kinase; PFAM: Chromatin associated protein KTI12; KEGG: hypothetical protein. | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.475 |
| endA | ACV25276.1 | Mefer_1397 | Mefer_1473 | tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. | 0.447 |
| endA | taw2 | Mefer_1397 | Mefer_1490 | tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Protein of unknown function Met10; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). | 0.504 |
| endA | taw3 | Mefer_1397 | Mefer_0050 | tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.480 |
| hacB | ACV23893.1 | Mefer_0048 | Mefer_0051 | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | PFAM: ERCC4 domain protein; helix-hairpin-helix motif; DEAD/DEAH box helicase domain protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; Helix-hairpin-helix DNA-binding class 1; KEGG: hypothetical protein; K10896 fanconi anemia group M protein. | 0.480 |
| hacB | rgy | Mefer_0048 | Mefer_0049 | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.752 |
| hacB | taw3 | Mefer_0048 | Mefer_0050 | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.515 |
| rgy | ACV23893.1 | Mefer_0049 | Mefer_0051 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | PFAM: ERCC4 domain protein; helix-hairpin-helix motif; DEAD/DEAH box helicase domain protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; Helix-hairpin-helix DNA-binding class 1; KEGG: hypothetical protein; K10896 fanconi anemia group M protein. | 0.520 |
| rgy | hacB | Mefer_0049 | Mefer_0048 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.752 |
| rgy | taw3 | Mefer_0049 | Mefer_0050 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | 0.609 |
