Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV23901.1PFAM: metallophosphoesterase; KEGG: scl:sce7256 putative protein phosphatase. (239 aa)    
Predicted Functional Partners:
ACV24253.1
PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: cpsf3; DNA repair metallo-beta-lactamase domain-containing protein.
  
 0.818
ACV24033.1
PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: cleavage and polyadenylation specificity factor.
   
 0.817
eif2a
Translation initiation factor 2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
  
 
 0.794
rpl14e
KEGG: hypothetical protein; K02875 large subunit ribosomal protein L14e; Belongs to the eukaryotic ribosomal protein eL14 family.
    
 0.734
rpl3
Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
  
 0.721
ACV25036.1
TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1; KEGG: cct3; chaperonin subunit 3 (gamma); K09495 T-complex protein 1 subunit gamma.
  
 
 0.702
ACV23903.1
KEGG: gbm:Gbem_1667 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein.
   
 
 0.650
ACV24426.1
PFAM: sodium/hydrogen exchanger; KEGG: cja:CJA_2911 putative pH regulated Na(+)/H(+) antiporter.
   
 
 0.644
ACV25223.1
KEGG: gur:Gura_3491 GTPase or GTP-binding protein-like protein.
     
 0.604
hisS
KEGG: hypothetical protein; K01892 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
 
 0.596
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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