Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV23938.1KEGG: sun:SUN_0573 fumarate/tartrate hydratase, alpha subunit; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region. (299 aa)    
Predicted Functional Partners:
ACV24050.1
KEGG: ebr:ECB_02932 L(+)-tartrate dehydratase; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region.
 0.999
ACV24540.1
PFAM: Lactate/malate dehydrogenase; KEGG: ama:AM564 malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 
 0.984
ACV25047.1
PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: vap:Vapar_5615 fumarate reductase/succinate dehydrogenase flavoprotein domain protein.
  
 
 0.976
ACV24224.1
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; ferredoxin; KEGG: ppd:Ppro_2541 hypothetical protein.
    
 0.910
argH
TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: gur:Gura_0231 argininosuccinate lyase.
    
 0.833
ACV24643.1
PFAM: aminotransferase class I and II; KEGG: nis:NIS_0815 aspartate aminotransferase.
    
 0.812
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.710
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
  
 0.646
ACV24397.1
TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; KEGG: hch:HCH_06704 pyruvate carboxylase subunit B.
     
 0.638
ACV24455.1
KEGG: sfu:Sfum_3649 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein.
     
 0.612
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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