Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV23943.1KEGG: scl:sce7306 hypothetical protein. (169 aa)    
Predicted Functional Partners:
ACV23942.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: sdn:Sden_1162 thiamine pyrophosphate enzyme-like TPP-binding.
  
 0.999
ACV25203.1
PFAM: Malate/L-lactate dehydrogenase; KEGG: sat:SYN_02526 malate/L-lactate dehydrogenase.
    
 0.947
taw1
Wyosine base formation domain protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
       0.880
ACV23944.1
PFAM: (2R)-phospho-3-sulfolactate synthase ComA; KEGG: phosphosulfolactate synthase.
  
  
 0.859
ACV24773.1
PFAM: DNA topoisomerase type IA zn finger domain protein; KEGG: hso:HS_1737 DNA topoisomerase III.
  
    0.699
cofG
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
      
 0.663
ACV23940.1
PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: pca:Pcar_1215 hypothetical protein.
       0.661
mtrB
Tetrahydromethanopterin S-methyltransferase; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
      
 0.661
mtrD
Tetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
      
 0.652
mtrE
Tetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
      
 0.642
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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