Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV23944.1PFAM: (2R)-phospho-3-sulfolactate synthase ComA; KEGG: phosphosulfolactate synthase. (251 aa)    
Predicted Functional Partners:
ACV24633.1
KEGG: cbs:COXBURSA331_A1552 2-phosphosulfolactate phosphatase; TIGRFAM: 2-phosphosulfolactate phosphatase; PFAM: 2-phosphosulfolactate phosphatase.
 
 
 0.990
ACV24977.1
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: glo:Glov_1037 ABC transporter related.
  
    0.970
ACV24978.1
PFAM: cobalamin synthesis protein P47K; KEGG: glo:Glov_1036 cobalamin synthesis protein P47K.
  
    0.961
ACV24979.1
PFAM: Fe-S cluster domain protein; KEGG: geo:Geob_2527 Fe-S cluster domain protein.
 
    0.961
ACV23943.1
KEGG: scl:sce7306 hypothetical protein.
  
  
 0.859
ACV24803.1
TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; KEGG: hch:HCH_00076 hydrogenase accessory protein HypB.
  
    0.828
ACV24773.1
PFAM: DNA topoisomerase type IA zn finger domain protein; KEGG: hso:HS_1737 DNA topoisomerase III.
  
    0.820
ACV23942.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: sdn:Sden_1162 thiamine pyrophosphate enzyme-like TPP-binding.
  
  
 0.758
pgk2
PFAM: ATP-cone domain protein; KEGG: hypothetical protein.
      
 0.640
taw1
Wyosine base formation domain protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
       0.496
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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