close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACV23975.1PFAM: protein of unknown function DUF129. (308 aa)    
Predicted Functional Partners:
cofE
F420-dependent oxidoreductase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
  
  
  0.767
ACV25139.1
Phosphate uptake regulator, PhoU; PFAM: PhoU family protein; KEGG: cti:RALTA_A1971 negative regulator of PhoR/PhoB two-component regulator.
  
     0.614
ACV24831.1
PFAM: glucose-methanol-choline oxidoreductase; KEGG: ppr:PBPRB1949 hypothetical protein.
  
     0.567
ACV24037.1
TIGRFAM: pyridoxal phosphate enzyme; KEGG: spl:Spea_0442 selenocysteine synthase.
  
     0.561
ACV23976.1
Hypothetical protein.
       0.547
ACV24193.1
PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: gur:Gura_0041 cobyric acid synthase CobQ.
  
    0.534
cofC
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
  
     0.508
ACV24134.1
PFAM: regulatory protein LysR; KEGG: pin:Ping_2047 transcriptional regulator, substrate-binding of LysR family protein.
  
    0.487
ACV23977.1
PFAM: Circadian clock protein KaiC central region; KaiA binding; KEGG: bbt:BBta_6554 circadian clock protein KaiC; Belongs to the UPF0273 family.
       0.486
ACV25137.1
PFAM: Queuosine synthesis-like; KEGG: cjd:JJD26997_1992 hypothetical protein.
 
     0.472
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.