Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV23983.1PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pub:SAR11_0383 tRNA-i(6)A37 modification enzyme. (511 aa)    
Predicted Functional Partners:
ACV24769.1
PFAM: deoxyribonuclease/rho motif-related TRAM; KEGG: dol:Dole_1585 RNA methyltransferase.
 
     0.561
ACV25134.1
PFAM: TrkA-N domain protein; phosphoesterase DHHA1; phosphoesterase RecJ domain protein; KEGG: dol:Dole_0370 phosphoesterase domain-containing protein.
 
     0.531
ACV23982.1
KEGG: hypothetical protein.
       0.498
mptE
Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
       0.498
cimA
Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
       0.486
trmY
Protein of unknown function DUF358; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family.
  
     0.479
ACV25059.1
PFAM: Radical SAM domain protein; KEGG: pca:Pcar_1369 hypothetical protein.
 
     0.458
ACV24106.1
PFAM: NMD3 family protein.
  
     0.450
ACV23981.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: dal:Dalk_1629 2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
       0.432
ACV24746.1
PFAM: cysteine-rich small domain.
  
     0.417
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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