| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACV24570.1 | pan | Mefer_0752 | Mefer_0150 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 0.814 |
| ACV24570.1 | psmA | Mefer_0752 | Mefer_1376 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.848 |
| ACV24570.1 | psmB | Mefer_0752 | Mefer_0382 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.832 |
| ACV24570.1 | rad50 | Mefer_0752 | Mefer_0661 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.531 |
| ACV24570.1 | rpl40e | Mefer_0752 | Mefer_1082 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | Hypothetical protein; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.937 |
| ACV24570.1 | tuf | Mefer_0752 | Mefer_1271 | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | Translation elongation factor EF-1, subunit alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. | 0.416 |
| ACV25177.1 | pan | Mefer_1370 | Mefer_0150 | Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: similar to multiprotein bridging factor 1 CG4143-PA, isoform A; K03627 putative transcription factor. | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 0.737 |
| ACV25177.1 | rpl40e | Mefer_1370 | Mefer_1082 | Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: similar to multiprotein bridging factor 1 CG4143-PA, isoform A; K03627 putative transcription factor. | Hypothetical protein; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.917 |
| ACV25177.1 | rps5 | Mefer_1370 | Mefer_0676 | Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: similar to multiprotein bridging factor 1 CG4143-PA, isoform A; K03627 putative transcription factor. | Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. | 0.861 |
| ACV25177.1 | tgtA | Mefer_1370 | Mefer_0980 | Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: similar to multiprotein bridging factor 1 CG4143-PA, isoform A; K03627 putative transcription factor. | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.861 |
| ACV25177.1 | tuf | Mefer_1370 | Mefer_1271 | Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: similar to multiprotein bridging factor 1 CG4143-PA, isoform A; K03627 putative transcription factor. | Translation elongation factor EF-1, subunit alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. | 0.589 |
| pan | ACV24570.1 | Mefer_0150 | Mefer_0752 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase. | 0.814 |
| pan | ACV25177.1 | Mefer_0150 | Mefer_1370 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: similar to multiprotein bridging factor 1 CG4143-PA, isoform A; K03627 putative transcription factor. | 0.737 |
| pan | psmA | Mefer_0150 | Mefer_1376 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.962 |
| pan | psmB | Mefer_0150 | Mefer_0382 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.971 |
| pan | pyrG | Mefer_0150 | Mefer_0152 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.781 |
| pan | rad50 | Mefer_0150 | Mefer_0661 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.762 |
| pan | rpl40e | Mefer_0150 | Mefer_1082 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Hypothetical protein; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.934 |
| pan | rps5 | Mefer_0150 | Mefer_0676 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. | 0.698 |
| pan | tgtA | Mefer_0150 | Mefer_0980 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.816 |
