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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
ACV24000.1PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dat:HRM2_02010 Fdx4. (355 aa)    
Predicted Functional Partners:
ACV23997.1
TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; KEGG: noc:Noc_0024 DNA/RNA non-specific endonuclease.
  
 0.999
ACV23998.1
PFAM: molydopterin dinucleotide-binding region; KEGG: cco:CCC13826_2031 putative Myb2 protein.
 
 0.999
ACV23999.1
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sfu:Sfum_0821 response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
 
 
 0.999
ACV24001.1
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dat:HRM2_45080 putative dissimilatory sulfite reductase.
  
 
 0.999
ACV23995.1
KEGG: mca:MCA2857 formylmethanofurane dehydrogenase subunit, putative; TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: glutamate synthase alpha subunit domain protein.
  
 0.996
ACV24081.1
KEGG: noc:Noc_0025 formylmethanofuran dehydrogenase; Contains selenocysteine; TIGRFAM: formylmethanofuran dehydrogenase subunit B; PFAM: molybdopterin oxidoreductase.
 
 0.993
ACV24376.1
PFAM: formylmethanofuran dehydrogenase subunit E region; KEGG: dal:Dalk_3123 formylmethanofuran dehydrogenase subunit E region.
    
 0.920
ftr
Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
    
 0.906
ACV24933.1
KEGG: nis:NIS_0688 succinate dehydrogenase/fumarate reductase, subunit C; TIGRFAM: CoB/CoM heterodisulfide reductase, subunit B; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein.
   
 
 0.865
ACV24076.1
4Fe-4S ferredoxin iron-sulfur binding domain protein; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
  
   0.864
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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