| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACV23889.1 | nadK | Mefer_0047 | Mefer_0065 | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.609 |
| ACV23889.1 | nth | Mefer_0047 | Mefer_0216 | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.499 |
| ACV23889.1 | queC | Mefer_0047 | Mefer_0176 | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.996 |
| ACV23889.1 | queE | Mefer_0047 | Mefer_0262 | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.999 |
| ACV23889.1 | tgtA | Mefer_0047 | Mefer_0980 | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.719 |
| ACV23889.1 | tmk | Mefer_0047 | Mefer_0667 | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | KEGG: wpi:WPa_0905 thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: thymidylate kinase. | 0.714 |
| ACV24014.1 | queC | Mefer_0175 | Mefer_0176 | KEGG: dat:HRM2_45740 GlnA2; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.576 |
| ACV24014.1 | tmk | Mefer_0175 | Mefer_0667 | KEGG: dat:HRM2_45740 GlnA2; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. | KEGG: wpi:WPa_0905 thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: thymidylate kinase. | 0.409 |
| ACV24364.1 | queC | Mefer_0543 | Mefer_0176 | PFAM: N-6 DNA methylase; restriction modification system DNA specificity domain; KEGG: wsu:WS1649 DNA methylase-type I restriction-modification system. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.506 |
| cofC | queC | Mefer_1466 | Mefer_0176 | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.560 |
| crcB | queC | Mefer_0588 | Mefer_0176 | CrcB protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.861 |
| nadK | ACV23889.1 | Mefer_0065 | Mefer_0047 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | 0.609 |
| nadK | nth | Mefer_0065 | Mefer_0216 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.619 |
| nadK | queC | Mefer_0065 | Mefer_0176 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.527 |
| nadK | tgtA | Mefer_0065 | Mefer_0980 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.643 |
| nth | ACV23889.1 | Mefer_0216 | Mefer_0047 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; KEGG: hypothetical protein similar to 6-pyruvoyl tetrahydropterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase. | 0.499 |
| nth | nadK | Mefer_0216 | Mefer_0065 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.619 |
| nth | queC | Mefer_0216 | Mefer_0176 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.545 |
| nth | queE | Mefer_0216 | Mefer_0262 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.515 |
| nth | tgtA | Mefer_0216 | Mefer_0980 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.517 |
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