Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV24016.1PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dal:Dalk_2982 coenzyme F420 hydrogenase. (357 aa)    
Predicted Functional Partners:
ACV24017.1
PFAM: glutamate synthase alpha subunit domain protein; KEGG: dde:Dde_1816 glutamate synthase (NADPH) GltB3 subunit.
  
    0.995
ACV25049.1
TIGRFAM: coenzyme F420 hydrogenase, subunit gamma; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sfu:Sfum_2715 NADH ubiquinone oxidoreductase, 20 kDa subunit.
 
 0.979
ACV25051.1
Contains selenocysteine; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; PFAM: nickel-dependent hydrogenase large subunit; KEGG: gem:GM21_3972 nickel-dependent hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 0.973
mer
5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
 
 
 0.971
ACV24018.1
PFAM: ferredoxin-dependent glutamate synthase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dvu:DVU1823 glutamate synthase, iron-sulfur cluster-binding subunit, putative; Belongs to the glutamate synthase family.
  
  
 0.956
mtd
Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
  
 
 0.949
ACV25050.1
TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit; hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; KEGG: sfu:Sfum_2220 hydrogenase maturation protease.
 
 
 0.931
ACV23946.1
TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit; hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; KEGG: sfu:Sfum_2220 hydrogenase maturation protease.
  
 
 0.919
ACV25048.1
TIGRFAM: coenzyme F420 hydrogenase, subunit beta; PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; KEGG: dal:Dalk_4964 coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein.
  
  
0.916
ACV24019.1
PFAM: glutamine amidotransferase class-II; KEGG: dde:Dde_1815 glutamate synthase (NADPH) GltB1 subunit.
  
    0.860
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.