Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24021.1PFAM: Energy-converting hydrogenase B, subunit P. (94 aa)    
Predicted Functional Partners:
ACV24022.1
TIGRFAM: HAD superfamily (subfamily IA) hydrolase, TIGR02253; HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: fph:Fphi_0258 phosphoglycolate phosphatase.
       0.936
ACV23897.1
PFAM: Na+/H+ antiporter MnhB subunit-related protein; KEGG: gbm:Gbem_1675 Na+/H+ antiporter MnhB subunit-related protein.
       0.908
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
       0.807
ACV24024.1
PFAM: nuclease (SNase domain protein); SMART: nuclease (SNase domain protein); KEGG: cjd:JJD26997_0811 thermonuclease family protein.
       0.705
aroK
TIGRFAM: shikimate kinase; PFAM: GHMP kinase; GHMP kinase domain protein; KEGG: cco:CCC13826_1493 homoserine kinase.
       0.689
ACV23974.1
Formate hydrogenlyase subunit 4-like protein; KEGG: rhi:NGR_c10570 NADH dehydrogenase I chain H.
       0.607
ACV23894.1
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: nam:NAMH_1419 NADH dehydrogenase subunit I.
       0.581
ACV24020.1
Uncharacterized host factor I protein-like protein.
       0.529
ACV23899.1
PFAM: NADH/Ubiquinone/plastoquinone (complex I); KEGG: ech:ECH_0179 putative monovalent cation/H+ antiporter subunit D.
       0.504
ACV24026.1
PFAM: CobN/magnesium chelatase; KEGG: dal:Dalk_3520 cobaltochelatase.
       0.456
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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