Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ACV24024.1PFAM: nuclease (SNase domain protein); SMART: nuclease (SNase domain protein); KEGG: cjd:JJD26997_0811 thermonuclease family protein. (189 aa)    
Predicted Functional Partners:
aroK
TIGRFAM: shikimate kinase; PFAM: GHMP kinase; GHMP kinase domain protein; KEGG: cco:CCC13826_1493 homoserine kinase.
 
     0.954
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
       0.764
ACV24740.1
KEGG: sat:SYN_01979 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein.
     
 0.735
ACV24022.1
TIGRFAM: HAD superfamily (subfamily IA) hydrolase, TIGR02253; HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: fph:Fphi_0258 phosphoglycolate phosphatase.
     
 0.717
ACV24021.1
PFAM: Energy-converting hydrogenase B, subunit P.
       0.705
rps4
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
 
 
 
 0.677
rtcB
PFAM: protein of unknown function UPF0027; KEGG: sat:SYN_02046 RtcB protein; Belongs to the RtcB family.
     
 0.663
ACV23851.1
PFAM: polysaccharide biosynthesis protein; multi antimicrobial extrusion protein MatE; KEGG: pcr:Pcryo_0621 polysaccharide biosynthesis protein.
 
  
 0.605
rps5
Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
  
 
 0.593
ACV24102.1
PFAM: Transcription factor CBF/NF-Y/histone domain protein.
      
 0.573
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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