Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24027.1PFAM: Transcription factor CBF/NF-Y/histone domain protein; Histone core domain protein; TATA box binding protein associated factor (TAF); KEGG: hypothetical protein. (67 aa)    
Predicted Functional Partners:
thrS
TIGRFAM: threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; KEGG: tgr:Tgr7_1450 threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.552
ACV24028.1
TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: dat:HRM2_09200 MoaB.
       0.516
dtdA
Protein of unknown function DUF516; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
       0.516
albA
DNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family.
  
   
 0.463
ACV24801.1
PFAM: Protein of unknown function DUF63.
 
     0.462
ACV24026.1
PFAM: CobN/magnesium chelatase; KEGG: dal:Dalk_3520 cobaltochelatase.
       0.455
ACV24183.1
PFAM: protein of unknown function DUF75.
  
     0.445
atpE
H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
     0.445
ACV24567.1
PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: hypothetical protein; K07466 replication factor A1.
 
  
 0.431
ACV24030.1
PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: sat:SYN_00474 phosphoribosylaminoimidazole carboxylase NCAIR mutase subunit.
       0.426
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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