Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24033.1PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: cleavage and polyadenylation specificity factor. (421 aa)    
Predicted Functional Partners:
ACV25223.1
KEGG: gur:Gura_3491 GTPase or GTP-binding protein-like protein.
   
 0.906
ACV25208.1
PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; KEGG: nam:NAMH_1555 ATP-dependent RNA helicase DeaD; Belongs to the DEAD box helicase family.
  
 0.878
ACV23901.1
PFAM: metallophosphoesterase; KEGG: scl:sce7256 putative protein phosphatase.
   
 0.817
ACV24185.1
TIGRFAM: DNA helicase; SMART: DEAD-like helicase; KEGG: nam:NAMH_1081 putative DNA helicase.
   
 0.817
mre11
Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
 0.735
rpoP
RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
   
 0.680
rpl40e
Hypothetical protein; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 
  0.622
ACV24626.1
Transcription termination factor Tfs; KEGG: RPC11; DNA-directed RNA polymerase III; TIGRFAM: transcription factor S; PFAM: DNA-directed RNA polymerase, M/15 kDa subunit; Transcription factor TFIIS; SMART: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
  
 0.621
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 0.612
rpoH
RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
   
 0.612
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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