Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24082.1TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerization) domain; KEGG: pca:Pcar_1907 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (518 aa)    
Predicted Functional Partners:
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.978
leuC
Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 
 0.968
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.963
ilvD
KEGG: dol:Dole_2036 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.947
ACV25286.1
PFAM: Thiolase; KEGG: gur:Gura_4354 thiolase.
  
 
 0.940
ACV24034.1
KEGG: gme:Gmet_1261 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein.
  
 
 0.931
ACV23980.1
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: geo:Geob_1509 acetolactate synthase, large subunit, biosynthetic type.
  
 
 0.927
ACV24148.1
TIGRFAM: acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: sfu:Sfum_3454 acetate--CoA ligase.
  
 
 0.925
ACV23981.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: dal:Dalk_1629 2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.919
ACV24702.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: sfu:Sfum_2794 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
  
 
 0.914
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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