Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24099.1PFAM: Protein of unknown function DUF2115; Belongs to the UPF0305 family. (176 aa)    
Predicted Functional Partners:
ACV24098.1
PFAM: protein of unknown function DUF125 transmembrane; KEGG: dps:DP2435 hypothetical protein.
       0.980
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
       0.773
ACV24097.1
PFAM: Dimethylmenaquinone methyltransferase; KEGG: dvm:DvMF_2302 dimethylmenaquinone methyltransferase.
       0.743
ACV24096.1
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gem:GM21_0410 porphobilinogen synthase; Belongs to the ALAD family.
       0.681
ACV24101.1
PFAM: phosphoribosyltransferase; KEGG: orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase; K00762 orotate phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
       0.655
ACV24102.1
PFAM: Transcription factor CBF/NF-Y/histone domain protein.
       0.524
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
       0.496
ACV24095.1
PFAM: CutA1 divalent ion tolerance protein; KEGG: GF15955 gene product from transcript GF15955-RA; K03926 periplasmic divalent cation tolerance protein.
       0.492
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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