STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ACV24101.1PFAM: phosphoribosyltransferase; KEGG: orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase; K00762 orotate phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (207 aa)    
Predicted Functional Partners:
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
       0.917
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
       0.886
ACV24102.1
PFAM: Transcription factor CBF/NF-Y/histone domain protein.
     
 0.756
vapC
PilT protein domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.
 
     0.696
ACV24619.1
Transcriptional regulator, MarR family; PFAM: Helix-turn-helix type 11 domain protein; regulatory protein MarR; SMART: regulatory protein Crp; KEGG: asa:ASA_0900 carbohydrate kinase.
  
     0.686
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
       0.666
ACV24099.1
PFAM: Protein of unknown function DUF2115; Belongs to the UPF0305 family.
       0.655
ACV24098.1
PFAM: protein of unknown function DUF125 transmembrane; KEGG: dps:DP2435 hypothetical protein.
       0.641
ACV24097.1
PFAM: Dimethylmenaquinone methyltransferase; KEGG: dvm:DvMF_2302 dimethylmenaquinone methyltransferase.
       0.618
lysS
lysyl-tRNA synthetase; KEGG: noc:Noc_1618 lysine--tRNA ligase; TIGRFAM: lysyl-tRNA synthetase; PFAM: Lysyl-tRNA synthetase class 1c; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.609
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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