Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24124.1PFAM: Protein of unknown function UPF0058. (115 aa)    
Predicted Functional Partners:
guaAB
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
       0.773
ACV24123.1
TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein; KEGG: bpy:Bphyt_2187 UbiD family decarboxylase.
  
    0.626
ACV24126.1
Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.
       0.517
ACV24127.1
PFAM: protein of unknown function DUF59; KEGG: nis:NIS_1811 hypothetical protein.
       0.414
ACV24128.1
PFAM: D-glucuronyl C5-epimerase domain protein; KEGG: cha:CHAB381_1476 putative D-glucuronyl C5-epimerase (heparin/heparansulfate:glucuronic acid C5 epimerase).
       0.404
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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