Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24127.1PFAM: protein of unknown function DUF59; KEGG: nis:NIS_1811 hypothetical protein. (95 aa)    
Predicted Functional Partners:
ACV24126.1
Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.
       0.838
ACV24128.1
PFAM: D-glucuronyl C5-epimerase domain protein; KEGG: cha:CHAB381_1476 putative D-glucuronyl C5-epimerase (heparin/heparansulfate:glucuronic acid C5 epimerase).
       0.752
ACV25044.1
PFAM: ABC transporter related; SMC domain protein; SMART: AAA ATPase; KEGG: ftm:FTM_0976 SufS activator complex, SufC subunit.
 
  
 0.631
tgtA
Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
       0.526
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
       0.501
ACV25137.1
PFAM: Queuosine synthesis-like; KEGG: cjd:JJD26997_1992 hypothetical protein.
       0.501
ACV25286.1
PFAM: Thiolase; KEGG: gur:Gura_4354 thiolase.
  
  
 0.440
ACV25045.1
PFAM: SufBD protein; KEGG: dma:DMR_23420 SufBD family protein.
     
 0.428
guaAB
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
       0.418
ACV24124.1
PFAM: Protein of unknown function UPF0058.
       0.414
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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