Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24142.1PFAM: Protein of unknown function DUF530; KEGG: DNA double-strand break repair Rad50 ATPase; K02365 separase. (486 aa)    
Predicted Functional Partners:
cca
CCA-adding enzyme; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
  
    0.927
ACV24140.1
PFAM: Glycosyl transferase, family 4, conserved region; KEGG: cje:Cj0433c phospho-N-acetylmuramoyl-pentapeptide-transferase.
       0.858
ACV24138.1
TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; KEGG: wbr:WGLp587 asparagine synthetase B.
  
    0.690
ACV24139.1
PFAM: photosystem I assembly BtpA; KEGG: ara:Arad_9790 hypothetical protein.
       0.683
top6B
DNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
       0.609
ACV24804.1
KH domain protein; KEGG: RNA-binding protein; K06961; TIGRFAM: KH domain protein; PFAM: K Homology, type 1, subgroup; SMART: KH domain protein.
       0.609
ACV24805.1
KEGG: similar to predicted protein; PFAM: RIO-like kinase; SMART: protein of unknown function RIO1.
       0.609
eif1a
Translation initiation factor eIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
       0.609
mptA
Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
       0.609
top6A
DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
       0.609
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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