Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24149.1PP-loop superfamily cell cycle control ATPase-like protein; KEGG: abu:Abu_0688 putative LPS biosynthesis protein WbpG. (273 aa)    
Predicted Functional Partners:
ACV24822.1
PFAM: Radical SAM domain protein; KEGG: lpf:lpl0804 hypothetical protein.
 
   
 0.728
ACV25010.1
PFAM: Methyltransferase type 12; Methyltransferase type 11; KEGG: dat:HRM2_44560 UbiE6.
 
 
 0.642
pyrC
Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
       0.584
carS
Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
       0.563
ACV24151.1
PFAM: amino acid-binding ACT domain protein; KEGG: ank:AnaeK_3529 threonine dehydratase.
       0.563
ACV24422.1
Putative cell wall-binding domain protein-like protein; KEGG: hypothetical protein.
 
     0.556
pfkC
ADP-specific phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
  
     0.549
ACV24152.1
PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: rlt:Rleg2_5063 homoserine dehydrogenase.
     
 0.527
ACV24530.1
PFAM: protein of unknown function DUF364; KEGG: wsu:WS1156 hypothetical protein.
  
    0.513
ACV25342.1
TIGRFAM: L-seryl-tRNA(Sec) kinase; PFAM: Chromatin associated protein KTI12; KEGG: hypothetical protein.
  
 
 0.502
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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