Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24193.1PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: gur:Gura_0041 cobyric acid synthase CobQ. (483 aa)    
Predicted Functional Partners:
ACV24616.1
TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; KEGG: cvi:CV_1562 precorrin-3B C17-methyltransferase.
 
  
 0.880
ACV24852.1
TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: gme:Gmet_0482 precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase.
 
  
 0.856
ACV24582.1
PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: vsp:VS_2662 precorrin-8X methylmutase CbiC.
  
  
 0.820
ACV25326.1
KEGG: gur:Gura_0039 precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family.
  
  
 0.809
cbiD
Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.806
ACV24987.1
TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: stm:STM2027 precorrin-3B C17-methyltransferase.
  
  
 0.778
ACV24037.1
TIGRFAM: pyridoxal phosphate enzyme; KEGG: spl:Spea_0442 selenocysteine synthase.
 
     0.730
ACV24411.1
PFAM: Oligosaccharyl transferase STT3 subunit; KEGG: nam:NAMH_1652 oligosaccharyl transferase, STT3 subunit.
  
     0.725
ACV25139.1
Phosphate uptake regulator, PhoU; PFAM: PhoU family protein; KEGG: cti:RALTA_A1971 negative regulator of PhoR/PhoB two-component regulator.
  
     0.706
ACV24134.1
PFAM: regulatory protein LysR; KEGG: pin:Ping_2047 transcriptional regulator, substrate-binding of LysR family protein.
 
  
 0.702
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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